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dc.contributor.authorMasselli, E.
dc.contributor.authorPozzi, G.
dc.contributor.authorVaccarezza, Mauro
dc.contributor.authorMirandola, P.
dc.contributor.authorGalli, D.
dc.contributor.authorVitale, M.
dc.contributor.authorCarubbi, C.
dc.contributor.authorGobbi, G.
dc.date.accessioned2020-07-23T07:29:59Z
dc.date.available2020-07-23T07:29:59Z
dc.date.issued2020
dc.identifier.citationMasselli, E. and Pozzi, G. and Vaccarezza, M. and Mirandola, P. and Galli, D. and Vitale, M. and Carubbi, C. et al. 2020. ROS in platelet biology: Functional aspects and methodological insights. International Journal of Molecular Sciences. 21 (14): pp. 1-35.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/80185
dc.identifier.doi10.3390/ijms21144866
dc.description.abstract

© 2020 by the authors.

Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet functions. Platelet activation determines a drastic change in redox balance and in platelet metabolism. Indeed, several signaling pathways have been demonstrated to induce ROS production by NAPDH oxidase (NOX) and mitochondria, upon platelet activation. Platelet-derived ROS, in turn, boost further ROS production and consequent platelet activation, adhesion and recruitment in an auto-amplifying loop. This vicious circle results in a platelet procoagulant phenotype and apoptosis, both accounting for the high thrombotic risk in oxidative stress-related diseases. This review sought to elucidate molecular mechanisms underlying ROS production upon platelet activation and the effects of an altered redox balance on platelet function, focusing on the main advances that have been made in platelet redox biology. Furthermore, given the increasing interest in this field, we also describe the up-to-date methods for detecting platelets, ROS and the platelet bioenergetic profile, which have been proposed as potential disease biomarkers.

dc.languageeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectROS
dc.subjectmitochondria
dc.subjectoxidative stress
dc.subjectplatelet
dc.titleROS in platelet biology: Functional aspects and methodological insights
dc.typeJournal Article
dcterms.source.volume21
dcterms.source.number14
dcterms.source.startPage1
dcterms.source.endPage35
dcterms.source.issn1661-6596
dcterms.source.titleInternational Journal of Molecular Sciences
dc.date.updated2020-07-23T07:29:58Z
curtin.note

Published by MDPI Publishing.

curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
dcterms.source.eissn1422-0067
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]


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