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dc.contributor.authorSmoothy, J.
dc.contributor.authorLarcombe, Alexander
dc.contributor.authorChivers, E.K.
dc.contributor.authorMatthews, V.B.
dc.contributor.authorGorman, S.
dc.identifier.citationSmoothy, J. and Larcombe, A.N. and Chivers, E.K. and Matthews, V.B. and Gorman, S. 2019. Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice). Respiratory Research. 20 (1): Article No. 21.

© 2019 The Author(s). Published in Respiratory Research.

Background: Epidemiological studies have identified strong relationships between maternal obesity and offspring respiratory dysfunction; however, the causal direction is not known. We tested whether maternal obesity alters respiratory function of offspring in early life. Methods: Female C57Bl/6 J mice were fed a high or low fat diet prior to and during two rounds of mating and resulting pregnancies with offspring lung function assessed at 2 weeks of age. The lung function of dams was measured at 33 weeks of age. Results: A high fat diet caused significant weight gain prior to conception with dams exhibiting elevated fasting glucose, and glucose intolerance. The number of surviving litters was significantly less for dams fed a high fat diet, and surviving offspring weighed more, were longer and had larger lung volumes than those born to dams fed a low fat diet. The larger lung volumes significantly correlated in a linear fashion with body length. Pups born from the second pregnancy had reduced tissue elastance compared to pups born from the first pregnancy, regardless of the dam's diet. As there was reduced offspring survival born to dams fed a high fat diet, the statistical power of lung function measures of offspring was limited. There were signs of increased inflammation in the bronchoalveolar lavage fluid of dams (but not offspring) fed a high fat diet, with more tumour necrosis factor-α, interleukin(IL)-5, IL-33 and leptin detected. Dams that were fed a high fat diet and became pregnant twice had reduced fasting glucose immediately prior to the second mating, and lower levels of IL-33 and leptin in bronchoalveolar lavage fluid. Conclusions: While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring. Further studies are required to examine downstream effects of this enhanced lung volume on respiratory function in disease settings.

dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectRespiratory System
dc.subjectMaternal obesity
dc.subjectLung function
dc.subjectLung development
dc.subjectImmune training
dc.titleMaternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)
dc.typeJournal Article
dcterms.source.titleRespiratory Research
curtin.departmentSchool of Public Health
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidLarcombe, Alexander [0000-0003-4196-4482]
curtin.contributor.researcheridLarcombe, Alexander [A-7704-2011]
curtin.identifier.article-numberARTN 21
curtin.contributor.scopusauthoridLarcombe, Alexander [6508025368]

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