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dc.contributor.authorVaccarezza, Mauro
dc.contributor.authorPapa, V.
dc.contributor.authorMarracino, L.
dc.contributor.authorFortini, F.
dc.contributor.authorRizzo, P.
dc.contributor.authorCampo, G.
dc.contributor.authorVieceli Dalla Sega, F
dc.date.accessioned2020-08-13T07:08:43Z
dc.date.available2020-08-13T07:08:43Z
dc.date.issued2020
dc.identifier.citationPapa, V.; Marracino, L.; Fortini, F.; Rizzo, P.; Campo, G.; Vaccarezza, M.; Vieceli Dalla Sega, F. 2020. Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review. Journal of Clinical Medicine. 9 (8): Article No. 2480.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/80534
dc.identifier.doi10.3390/jcm9082480
dc.description.abstract

Some random mutations can confer a selective advantage to a hematopoietic stem cell. As a result, mutated hematopoietic stem cells can give rise to a significant proportion of mutated clones of blood cells. This event is known as “clonal hematopoiesis.” Clonal hematopoiesis is closely associated with age, and carriers show an increased risk of developing blood cancers. Clonal hematopoiesis of indeterminate potential is defined by the presence of clones carrying a mutation associated with a blood neoplasm without obvious hematological malignancies. Unexpectedly, in recent years, it has emerged that clonal hematopoiesis of indeterminate potential carriers also have an increased risk of developing cardiovascular disease. Mechanisms linking clonal hematopoiesis of indeterminate potential to cardiovascular disease are only partially known. Findings in animal models indicate that clonal hematopoiesis of indeterminate potential-related mutations amplify inflammatory responses. Consistently, clinical studies have revealed that clonal hematopoiesis of indeterminate potential carriers display increased levels of inflammatory markers. In this review, we describe progress in our understanding of clonal hematopoiesis in the context of cancer, and we discuss the most recent findings linking clonal hematopoiesis of indeterminate potential and cardiovascular diseases.

dc.languageEnglish
dc.publisherMDPI AG
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleTranslating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number8
dcterms.source.issn2077-0383
dcterms.source.titleJournal of Clinical Medicine
dc.date.updated2020-08-13T07:08:42Z
curtin.note

© Authors. Published by MDPI Publishing.

curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
curtin.identifier.article-number2480
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]


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