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    Immunogenicity of the inactivated influenza vaccine in children who have undergone autologous stem cell transplant

    Access Status
    Fulltext not available
    Authors
    Ryan, A.L.
    Wadia, U.D.
    Jacoby, P.
    Cheung, Laurence
    Kerr, F.
    Fraser, C.
    Tapp, H.
    Carolan, L.A.
    Laurie, K.L.
    Barr, I.G.
    Blyth, C.C.
    Gottardo, N.G.
    Richmond, P.C.
    Kotecha, Rishi
    Date
    2019
    Type
    Journal Article
    
    Metadata
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    Citation
    Ryan, A.L. and Wadia, U.D. and Jacoby, P. and Cheung, L.C. and Kerr, F. and Fraser, C. and Tapp, H. et al. 2019. Immunogenicity of the inactivated influenza vaccine in children who have undergone autologous stem cell transplant. Bone Marrow Transplantation. 55: pp. 1829-1831.
    Source Title
    Bone Marrow Transplantation
    DOI
    10.1038/s41409-019-0770-3
    ISSN
    0268-3369
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1142627
    http://purl.org/au-research/grants/nhmrc/1111596
    URI
    http://hdl.handle.net/20.500.11937/80804
    Collection
    • Curtin Research Publications
    Abstract

    CORRESPONDENCE

    To the Editor: Autologous stem cell transplant (SCT) is an upfront therapeutic modality for children with malignancies such as high-risk neuroblastoma and atypical teratoid rhabdoid tumour and a salvage option for children with lymphoma and a variety of solid tumours. The administration of highdose myeloablative chemotherapy during conditioning increases vulnerability to infection. Influenza infection can result in significant complications, in particular progression to pneumonia, in patients who have undergone autologous SCT [1, 2]. Influenza vaccination is recommended to prevent infection in children following autologous SCT [3], however, there is limited evidence regarding its benefit in this population [4]. Due to the paucity of data, we performed a prospective multicentre study to evaluate the immunogenicity of the seasonal inactivated influenza vaccine in children who have undergone autologous SCT compared with healthy matched controls.

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