Bile acid-based micro/nano capsules for the targeted oral delivery of probucol

Wagle, Susbin Raj

Wagle S 2020.pdf (13.24Mb)

Access Status

Open access

Authors

Wagle, Susbin Raj

Date

2020

Supervisor

Hani Al-Salami

Armin Mooranian

Type

Thesis

Award

MPhil

Metadata

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Faculty

Health Sciences

School

School of Pharmacy and Biomedical Sciences

Biotechnology and Drug Development Research Laboratory

Curtin Health Innovation Research Institute

URI

http://hdl.handle.net/20.500.11937/80870

Collection

Curtin Theses

Abstract

Probucol has shown its protective effect on pancreatic beta cells from inflammation and oxidation, but, it is a highly lipophilic oral drug with poor gut absorption and significant side effects that resulted in restrictions on its clinical prescribing. This study aimed to design new delivery systems for probucol using Lithocholic acid-based microcapsules to overcome these limitations and showed promising results.