An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles
dc.contributor.author | Smith, N.M. | |
dc.contributor.author | Gachulincova, I. | |
dc.contributor.author | Ho, D. | |
dc.contributor.author | Bailey, C. | |
dc.contributor.author | Bartlett, C.A. | |
dc.contributor.author | Norret, M. | |
dc.contributor.author | Murphy, J. | |
dc.contributor.author | Buckley, A. | |
dc.contributor.author | Rigby, P.J. | |
dc.contributor.author | House, M.J. | |
dc.contributor.author | Pierre, T.S. | |
dc.contributor.author | Fitzgerald, Melinda | |
dc.contributor.author | Iyer, K.S. | |
dc.contributor.author | Dunlop, S.A. | |
dc.date.accessioned | 2020-10-26T00:46:48Z | |
dc.date.available | 2020-10-26T00:46:48Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Smith, N.M. and Gachulincova, I. and Ho, D. and Bailey, C. and Bartlett, C.A. and Norret, M. and Murphy, J. et al. 2016. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles. Scientific Reports. 6: Article No. 22595. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/81495 | |
dc.identifier.doi | 10.1038/srep22595 | |
dc.description.abstract |
© 2016 The Authors. The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable. | |
dc.language | English | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.relation.sponsoredby | http://purl.org/au-research/grants/nhmrc/1028681 | |
dc.relation.sponsoredby | http://purl.org/au-research/grants/nhmrc/1087114 | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Science & Technology | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | CENTRAL-NERVOUS-SYSTEM | |
dc.subject | SECONDARY DEGENERATION | |
dc.subject | IN-VIVO | |
dc.subject | NEUROLOGICAL DISEASES | |
dc.subject | DELIVERY | |
dc.subject | INJURY | |
dc.subject | CONTRIBUTE | |
dc.subject | TRANSPORT | |
dc.subject | IMMUNE | |
dc.subject | DRUGS | |
dc.title | An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles | |
dc.type | Journal Article | |
dcterms.source.volume | 6 | |
dcterms.source.issn | 2045-2322 | |
dcterms.source.title | Scientific Reports | |
dc.date.updated | 2020-10-26T00:46:45Z | |
curtin.department | Office of the Pro Vice Chancellor Health Sciences | |
curtin.accessStatus | Open access | |
curtin.faculty | Faculty of Health Sciences | |
curtin.contributor.orcid | Fitzgerald, Melinda [0000-0002-4823-8179] | |
curtin.contributor.researcherid | Fitzgerald, Melinda [C-4235-2011] | |
curtin.identifier.article-number | ARTN 22595 | |
dcterms.source.eissn | 2045-2322 | |
curtin.contributor.scopusauthorid | Fitzgerald, Melinda [7402773604] |