Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases

Paternoster, Silvano

Paternoster S 2020.pdf (21.33Mb)

Access Status

Open access

Authors

Paternoster, Silvano

Date

2020

Supervisor

Marco Falasca

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

School of Pharmacy and Biomedical Sciences

Curtin Health Innovation Research Institute

URI

http://hdl.handle.net/20.500.11937/81689

Collection

Curtin Theses

Abstract

This PhD thesis discusses the study of a novel class of drugs for the treatment of metabolic diseases. We have characterized the pharmacology and biology of the lipid Oleoyl-lysophosphatidylinositol (Oleoyl-LPI), and we show that some synthetic molecules mimicking its structure, are efficient glucagon-like peptide-1 (GLP-1) secreting drugs in vitro and in vivo in diabetic mice. We have also dissected the pharmacology of Cannabis-derived drugs and demonstrated that they can also modulate GLP-1 secretion.