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dc.contributor.authorPaternoster, Silvano
dc.contributor.supervisorMarco Falascaen_US
dc.date.accessioned2020-11-13T06:22:53Z
dc.date.available2020-11-13T06:22:53Z
dc.date.issued2020en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11937/81689
dc.description.abstract

This PhD thesis discusses the study of a novel class of drugs for the treatment of metabolic diseases. We have characterized the pharmacology and biology of the lipid Oleoyl-lysophosphatidylinositol (Oleoyl-LPI), and we show that some synthetic molecules mimicking its structure, are efficient glucagon-like peptide-1 (GLP-1) secreting drugs in vitro and in vivo in diabetic mice. We have also dissected the pharmacology of Cannabis-derived drugs and demonstrated that they can also modulate GLP-1 secretion.

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dc.publisherCurtin Universityen_US
dc.titleLysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseasesen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Pharmacy and Biomedical Sciencesen_US
curtin.departmentCurtin Health Innovation Research Instituteen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US
curtin.contributor.orcidPaternoster, Silvano [0000-0003-1224-0258]en_US


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