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    Investigating Changes to the Post Translational Modification Status of Key Components of the ER Translocation Machinery in Saccharomyces Cerevisiae

    Stevens K 2019.pdf (11.47Mb)
    Access Status
    Open access
    Authors
    Stevens, Kofi Lewis Paul
    Date
    2019
    Supervisor
    Carl Mousley
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/82125
    Collection
    • Curtin Theses
    Abstract

    Dysfunction of the endoplasmic reticulum is commonly observed in disease, however, the exact nature in which this manifests requires further investigation. We have examined the role post translational modifications have in regulating multiple aspects of cellular biology using the model organism, Saccharomyces cerevisiae. This work highlights the complex nature of the endoplasmic reticulum, elucidating novel mechanisms whereby phosphorylation and glycosylation are able to modulate activity in response to changes in the cellular environment.

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