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dc.contributor.authorGebreyohannes, Eyob Alemayehu
dc.contributor.authorSalter, Sandra
dc.contributor.authorChalmers, Leanne
dc.contributor.authorBereznicki, Luke
dc.contributor.authorLee, Kenneth
dc.identifier.citationGebreyohannes, E.A. and Salter, S. and Chalmers, L. and Bereznicki, L. and Lee, K. 2020. Non-adherence to Thromboprophylaxis Guidelines in Atrial Fibrillation: A Narrative Review of the Extent of and Factors in Guideline Non-adherence. American Journal of Cardiovascular Drugs. 21: pp. 419–433.

Atrial fibrillation is the most common arrhythmia. It increases the risk of thromboembolism by up to fivefold. Guidelines provide evidence-based recommendations to effectively mitigate thromboembolic events using oral anticoagulants while minimizing the risk of bleeding. This review focuses on non-adherence to contemporary guidelines and the factors associated with guideline non-adherence. The extent of guideline non-adherence differs according to geographic region, healthcare setting, and risk stratification tools used. Guideline adherence has gradually improved over recent years, but a significant proportion of patients are still not receiving guideline-recommended therapy. Physician-related and patient-related factors (such as patient refusals, bleeding risk, older age, and recurrent falls) also contribute to guideline non-adherence, especially to undertreatment. Quality improvement initiatives that focus on undertreatment, especially in the primary healthcare setting, may help to improve guideline adherence.

dc.titleNon-adherence to Thromboprophylaxis Guidelines in Atrial Fibrillation: A Narrative Review of the Extent of and Factors in Guideline Non-adherence
dc.typeJournal Article
dcterms.source.titleAmerican Journal of Cardiovascular Drugs

This is a post-peer-review, pre-copyedit version of an article published in American Journal of Cardiovascular Drugs. The final authenticated version is available online at:

curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidChalmers, Leanne [0000-0002-2477-2190]
curtin.contributor.scopusauthoridChalmers, Leanne [55932906100]

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