Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank.

    Access Status
    Open access via publisher
    Authors
    Wang, Mengying
    Zhou, Tao
    Song, Yongze
    Li, Xiang
    Ma, Hao
    Hu, Yonghua
    Heianza, Yoriko
    Qi, Lu
    Date
    2021
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wang, M. and Zhou, T. and Song, Y. and Li, X. and Ma, H. and Hu, Y. and Heianza, Y. et al. 2021. Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank. European Heart Journal. 42 (16): pp. 1582–1591.
    Source Title
    European Heart Journal
    DOI
    10.1093/eurheartj/ehaa1031
    ISSN
    0195-668X
    Faculty
    Faculty of Humanities
    School
    School of Design and the Built Environment
    URI
    http://hdl.handle.net/20.500.11937/82710
    Collection
    • Curtin Research Publications
    Abstract

    AIMS: Little is known about the relation between the long-term joint exposure to various ambient air pollutants and the incidence of heart failure (HF). We aimed to assess the joint association of various air pollutants with HF risk and examine the modification effect of the genetic susceptibility. METHODS AND RESULTS: This study included 432 530 participants free of HF, atrial fibrillation, or coronary heart disease in the UK Biobank study. All participants were enrolled from 2006 to 2010 and followed up to 2018. The information on particulate matter (PM) with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), and between 2.5 and 10 µm (PM2.5-10) as well as nitrogen oxides (NO2 and NOx) was collected. We newly proposed an air pollution score to assess the joint exposure to the five air pollutants through summing each pollutant concentration weighted by the regression coefficients with HF from single-pollutant models. We also calculated the weighted genetic risk score of HF. During a median of 10.1 years (4 346 642 person-years) of follow-up, we documented 4201 incident HF. The hazard ratios (HRs) [95% confidence interval (CI)] of HF for a 10 µg/m3 increase in PM2.5, PM10, PM2.5-10, NO2, and NOx were 1.85 (1.34-2.55), 1.61 (1.30-2.00), 1.13 (0.80-1.59), 1.10 (1.04-1.15), and 1.04 (1.02-1.06), respectively. We found that the air pollution score was associated with an increased risk of incident HF in a dose-response fashion. The HRs (95% CI) of HF were 1.16 (1.05-1.28), 1.19 (1.08-1.32), 1.21 (1.09-1.35), and 1.31 (1.17-1.48) in higher quintile groups compared with the lowest quintile of the air pollution score (P trend <0.001). In addition, we observed that the elevated risk of HF associated with a higher air pollution score was strengthened by the genetic susceptibility to HF. CONCLUSION: Our results indicate that the long-term joint exposure to various air pollutants including PM2.5, PM10, PM2.5-10, NO2, and NOx is associated with an elevated risk of incident HF in an additive manner. Our findings highlight the importance to comprehensively assess various air pollutants in relation to the HF risk.

    Related items

    Showing items related by title, author, creator and subject.

    • Cardiovascular disease risk score prediction models for women and its applicability to Asians
      Goh, Louise; Dhaliwal, Satvinder; Wellborn, T.; Thompson, P.; Maycock, Bruce; Kerr, Deborah; Lee, Andy; Bertolatti, Dean; Slivkoff-Clark, Karin; Naheed, R; Coorey, Ranil; Della, Phillip (2014)
      Purpose: Although elevated cardiovascular disease (CVD) risk factors are associated with a higher risk of developing heart conditions across all ethnic groups, variations exist between groups in the distribution and ...
    • The sex-specific association between BMI and coronary heart disease: A systematic review and meta-analysis of 95 cohorts with 1·2 million participants
      Mongraw-Chaffin, M.; Peters, S.; Huxley, Rachel; Woodward, M. (2015)
      © 2015 Elsevier Ltd. Background: The risk of developing coronary heart disease differs by sex, and accumulating evidence suggests that sex differences exist in the effect of coronary risk factors on vascular risk. So far, ...
    • A systematic review of air pollution and incidence of out-of-hospital cardiac arrest
      Teng, T.; Williams, T.; Bremner, A.; Tohira, H.; Franklin, P.; Tonkin, A.; Jacobs, I.; Finn, Judith (2013)
      Introduction: Studies have linked air pollution with the incidence of acute coronary artery events and cardiovascular mortality but the association with out-of-hospital cardiac arrest (OHCA) is less clear. Aim: To examine ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.