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dc.contributor.authorLong, S.M.
dc.contributor.authorTull, D.L.
dc.contributor.authorDe Souza, D.P.
dc.contributor.authorKouremenos, K.A.
dc.contributor.authorDayalan, S.
dc.contributor.authorMcConville, M.J.
dc.contributor.authorHassell, K.L.
dc.contributor.authorPettigrove, V.J.
dc.contributor.authorGagnon, Marthe Monique
dc.date.accessioned2021-05-12T03:07:58Z
dc.date.available2021-05-12T03:07:58Z
dc.date.issued2020
dc.identifier.citationLong, S.M. and Tull, D.L. and De Souza, D.P. and Kouremenos, K.A. and Dayalan, S. and McConville, M.J. and Hassell, K.L. et al. 2020. Metabolomics provide sensitive insights into the impacts of low level environmental contamination on fish health—a pilot study. Metabolites. 10 (1): Article No. 24.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/83508
dc.identifier.doi10.3390/metabo10010024
dc.description.abstract

This exploratory study aims to investigate the health of sand flathead (Platycephalus bassensis) sampled from five sites in Port Phillip Bay, Australia using gas chromatography-mass spectrometry (GC-MS) metabolomics approaches. Three of the sites were the recipients of industrial, agricultural, and urban run-off and were considered urban sites, while the remaining two sites were remote from contaminant inputs, and hence classed as rural sites. Morphological parameters as well as polar and free fatty acid metabolites were used to investigate inter-site differences in fish health. Significant differences in liver somatic index (LSI) and metabolite abundance were observed between the urban and rural sites. Differences included higher LSI, an increased abundance of amino acids and energy metabolites, and reduced abundance of free fatty acids at the urban sites compared to the rural sites. These differences might be related to the additional energy requirements needed to cope with low-level contaminant exposure through energy demanding processes such as detoxification and antioxidant responses as well as differences in diet between the sites. In this study, we demonstrate that metabolomics approaches can offer a greater level of sensitivity compared to traditional parameters such as physiological parameters or biochemical markers of fish health, most of which showed no or little inter-site differences in the present study. Moreover, the metabolite responses are more informative than traditional biomarkers in terms of biological significance as disturbances in specific metabolic pathways can be identified.

dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectBiochemistry & Molecular Biology
dc.subjectbiomarkers
dc.subjectfatty acid metabolites
dc.subjectenergy metabolism
dc.subjectamino acids
dc.subjectmetals
dc.subjectdiet
dc.subjectflathead
dc.subjectPlatycephalus bassensis
dc.subjectPORT-PHILLIP BAY
dc.subjectFLATHEAD PLATYCEPHALUS-BASSENSIS
dc.subjectFRESH-WATER FISH
dc.subjectFATTY-ACIDS
dc.subjectCADMIUM EXPOSURE
dc.subjectDISPERSED OIL
dc.subjectEROD ACTIVITY
dc.subjectTRACE-METALS
dc.subjectLIZA-AURATA
dc.subjectMETABOLISM
dc.titleMetabolomics provide sensitive insights into the impacts of low level environmental contamination on fish health—a pilot study
dc.typeJournal Article
dcterms.source.volume10
dcterms.source.number1
dcterms.source.issn2218-1989
dcterms.source.titleMetabolites
dc.date.updated2021-05-12T03:07:53Z
curtin.note

© 2020 The Authors. Published by MDPI Publishing.

curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidGagnon, Marthe Monique [0000-0002-3190-5094]
curtin.contributor.researcheridGagnon, Marthe Monique [P-6078-2014]
curtin.identifier.article-numberARTN 24
dcterms.source.eissn2218-1989
curtin.contributor.scopusauthoridGagnon, Marthe Monique [35577908600] [57202474096]


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