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    Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy

    Alrehaily A 2021.pdf (14.03Mb)
    Access Status
    Open access
    Authors
    Alrehaily, Abdulwahed
    Date
    2021
    Supervisor
    Delia Nelson
    Connie Jackman
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Science and Engineering
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/84211
    Collection
    • Curtin Theses
    Abstract

    The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models were used to study the effect of immunotherapies involving interleukin-2 and anti-CD40 antibody on these cells’ relationships. The data show that hypoxia influences the function of these cells and their responses to immunotherapies.

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