Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy
The goal of this research was to develop in vitro mesothelioma models representing normoxic (20% O2) or hypoxic (2% O2) environments (likely representing a large mesothelioma tumour), to study the crosstalk between mesothelioma cells, tumour-associated macrophages and endothelial cells. The models were used to study the effect of immunotherapies involving interleukin-2 and anti-CD40 antibody on these cells’ relationships. The data show that hypoxia influences the function of these cells and their responses to immunotherapies.
|dc.title||Hypoxic Regions in Mesothelioma Likely Modulate Cross-Talk between Tumour Cells, Macrophages and Endothelial Cells and Regulate Responses to Immunotherapy||en_US|
|curtin.department||Curtin Medical School||en_US|
|curtin.faculty||Science and Engineering||en_US|