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dc.contributor.authorPalmer, R.D.
dc.contributor.authorElnashar, Magdy
dc.contributor.authorVaccarezza, Mauro
dc.identifier.citationPalmer, R.D. and Elnashar, M.M. and Vaccarezza, M. 2021. Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging. Aging Medicine.

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in every human cell and regulates a number of systems across multiple cellular compartments and tissue types via an endogenous and exogenous influence. NAD levels are demonstrated to decline with age and therefore measures to counteract the waning of NAD have been devised. A number of NAD precursor candidates such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), the reduced form of nicotinamide mononucleotide (NMNH), nicotinic acid (NA) nicotinamide (NAM), and dihydronicotinamide riboside (DNR) increase NAD levels in vitro and in vivo. This discussion will focus on the precursors NR, NMN, NMNH, and DNR in the upregulation of NAD. There are many publications on NAD precursors as it has become popular for human consumption in recent years due to its vital importance to the general consumer. However, there is no consensus between researchers and this was the aim of this review, to determine and discuss their areas of agreement versus disagreement, to highlight the gaps in research, and to give recommendations for future work. Bioavailability and potency of NR, NMNH, NMN, and DNR is also examined on the light of the most recent literature.

dc.titlePrecursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging
dc.typeJournal Article
dcterms.source.titleAging Medicine
curtin.departmentCurtin College Pathways
curtin.departmentCurtin Medical School
curtin.accessStatusOpen access
curtin.facultyCurtin International
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidElnashar, Magdy [0000-0001-9936-3271]
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
curtin.contributor.scopusauthoridElnashar, Magdy [6507505187]
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]

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