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dc.contributor.authorSorsdahl, K.
dc.contributor.authorStein, D.J.
dc.contributor.authorPasche, S.
dc.contributor.authorJacobs, Y.
dc.contributor.authorKader, R.
dc.contributor.authorOdlaug, B.
dc.contributor.authorRichter, S.
dc.contributor.authorMyers-Franchi, Bronwyn
dc.contributor.authorGrant, J.E.
dc.identifier.citationSorsdahl, K. and Stein, D.J. and Pasche, S. and Jacobs, Y. and Kader, R. and Odlaug, B. and Richter, S. et al. 2021. A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial. Addiction Science and Clinical Practice. 16 (1): Article No. 3.

Background: Effective brief treatments for methamphetamine use disorders (MAUD) are urgently needed to complement longer more intensive treatments in low and middle income countries, including South Africa. To address this gap, the purpose of this randomised feasibility trial was to determine the feasibility of delivering a six-session blended imaginal desensitisation, plus motivational interviewing (IDMI) intervention for adults with a MAUD.

Methods: We enrolled 60 adults with a MAUD and randomly assigned them 1:1 to the IDMI intervention delivered by clinical psychologists and a control group who we referred to usual care. Feasibility measures, such as rates of recruitment, consent to participate in the trial and retention, were calculated. Follow-up interviews were conducted at 6 weeks and 3 months post-enrollment.

Results: Over 9 months, 278 potential participants initiated contact. Following initial screening 78 (28%) met inclusion criteria, and 60 (77%) were randomised. Thirteen of the 30 participants assigned to the treatment group completed the intervention. Both psychologists were highly adherent to the intervention, obtaining a fidelity rating of 91%. In total, 39 (65%) participants completed the 6-week follow-up and 40 (67%) completed the 3-month follow-up. The intervention shows potential effectiveness in the intention-to-treat analysis where frequency of methamphetamine use was significantly lower in the treatment than in the control group at both the 6 week and 3-month endpoints. No adverse outcomes were reported.

Conclusions: This feasibility trial suggests that the locally adapted IDMI intervention is an acceptable and safe intervention as a brief treatment for MAUD in South Africa. Modifications to the study design should be considered in a fully powered, definitive controlled trial to assess this potentially effective intervention. Trial registration The trial is registered with the Pan African Clinical Trials Registry (Trial ID: PACTR201310000589295)

dc.subjectBrief treatment
dc.subjectFeasibility trial
dc.subjectSouth Africa
dc.subjectSubstance use
dc.subjectAmphetamine-Related Disorders
dc.subjectCrisis Intervention
dc.subjectFeasibility Studies
dc.subjectImplosive Therapy
dc.subjectIntention to Treat Analysis
dc.subjectMotivational Interviewing
dc.subjectSouth Africa
dc.titleA novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial
dc.typeJournal Article
dcterms.source.titleAddiction Science and Clinical Practice

© The Author(s). 2021 Published in Addiction Science & Clinical Practice. This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License Please refer to the licence to obtain terms for any further reuse or distribution of this work.

curtin.departmentEnAble Institute
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidMyers-Franchi, Bronwyn [0000-0003-0235-6716]
curtin.contributor.scopusauthoridMyers-Franchi, Bronwyn [7202684194]

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