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dc.contributor.authorParkin, K.
dc.contributor.authorChristophersen, Claus
dc.contributor.authorVerhasselt, V.
dc.contributor.authorCooper, M.N.
dc.contributor.authorMartino, D.
dc.date.accessioned2021-11-18T07:55:17Z
dc.date.available2021-11-18T07:55:17Z
dc.date.issued2021
dc.identifier.citationParkin, K. and Christophersen, C.T. and Verhasselt, V. and Cooper, M.N. and Martino, D. 2021. Risk factors for gut dysbiosis in early life. Microorganisms. 9 (10): Article No. 2066.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/86498
dc.identifier.doi10.3390/microorganisms9102066
dc.description.abstract

Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbiosis of the intestinal microbiota can have a substantial effect on the nervous and immune systems, contributing to the onset of several inflammatory diseases. Epidemiological studies provided insight in how changes in the living environment have contributed to an overall loss of diversity and key taxa in the gut microbiome, coinciding with increased reports of atopy and allergic diseases. The gut microbiome begins development at birth, with major transition periods occurring around the commencement of breastfeeding, and the introduction of solid foods. As such, the development of the gut microbiome remains highly plastic and easily influenced by environmental factors until around three years of age. Developing a diverse and rich gut microbiome during this sensitive period is crucial to setting up a stable gut microbiome into adulthood and to prevent gut dysbiosis. Currently, the delivery route, antibiotic exposure, and diet are the best studied drivers of gut microbiome development, as well as risk factors of gut dysbiosis during infancy. This review focuses on recent evidence regarding key environmental factors that contribute to promoting gut dysbiosis.

dc.languageeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectatopy
dc.subjectgut dysbiosis
dc.subjectgut microbiome
dc.subjectinflammatory disease
dc.titleRisk factors for gut dysbiosis in early life
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number10
dcterms.source.issn2076-2607
dcterms.source.titleMicroorganisms
dc.date.updated2021-11-18T07:55:16Z
curtin.note

© 2021 The Authors. Published by MDPI Publishing.

curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidChristophersen, Claus [0000-0003-1591-5871]
dcterms.source.eissn2076-2607
curtin.contributor.scopusauthoridChristophersen, Claus [7006206487]


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