The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease

Shirolkar, Gayatri Dhananjay

Shirolkar GD 2021.pdf (15.70Mb)

Access Status

Open access

Authors

Shirolkar, Gayatri Dhananjay

Date

2021

Supervisor

Nina Tirnitz-Parker

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

Curtin Medical School

URI

http://hdl.handle.net/20.500.11937/86615

Collection

Curtin Theses

Abstract

This study established a regulatory role for the Wnt/ß-catenin pathway in liver progenitor cells (LPCs) in cell culture and in vivo models of non-alcoholic fatty liver disease and demonstrated a significant potential for therapeutic targeting of LPCs with the Wnt inhibitor PRI-724 to inhibit chronic liver disease progression.