The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease
| dc.contributor.author | Shirolkar, Gayatri Dhananjay | |
| dc.contributor.supervisor | Nina Tirnitz-Parker | en_US |
| dc.date.accessioned | 2021-11-25T05:20:03Z | |
| dc.date.available | 2021-11-25T05:20:03Z | |
| dc.date.issued | 2021 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/86615 | |
| dc.description.abstract |
This study established a regulatory role for the Wnt/ß-catenin pathway in liver progenitor cells (LPCs) in cell culture and in vivo models of non-alcoholic fatty liver disease and demonstrated a significant potential for therapeutic targeting of LPCs with the Wnt inhibitor PRI-724 to inhibit chronic liver disease progression. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | Curtin Medical School | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |
| curtin.contributor.orcid | Shirolkar, Gayatri Dhananjay [0000-0001-7728-4708] | en_US |