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    Investigations into the therapeutic potential of antimicrobial peptides: applications for treating topical Staphylococcus aureus infections

    235317_Ravensdale 2015.pdf (3.631Mb)
    Access Status
    Open access
    Authors
    Ravensdale, Joshua Thomas
    Date
    2015
    Supervisor
    Dr Frances O’Brien
    Prof. Elizabeth Watkin
    Dr Keith Gregg
    Collection
    • Curtin Theses
    Type
    Thesis
    Education Level
    PhD
    Metadata
    Show full item record
    Abstract

    In this study, resistance towards antimicrobial peptides developed rapidly in MRSA, but resistance was mitigated by controlling the environment in which the cells are treated. Resistance was not stable in a population and seemed to sensitise some cells to certain antibiotics. Antibacterial peptides enhanced the bactericidal effectiveness of an antibacterial gauze when used in tandem with a wetting agent and lysozyme. Results from this study suggest antibacterial peptides may have clinical applications as topical therapeutics.

    URI
    http://hdl.handle.net/20.500.11937/870
    Department
    School of Biomedical Sciences

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