Investigations into the therapeutic potential of antimicrobial peptides: applications for treating topical Staphylococcus aureus infections
Access Status
Open access
Authors
Ravensdale, Joshua Thomas
Date
2015Supervisor
Dr Frances O’Brien
Prof. Elizabeth Watkin
Dr Keith Gregg
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School of Biomedical Sciences
Collection
Abstract
In this study, resistance towards antimicrobial peptides developed rapidly in MRSA, but resistance was mitigated by controlling the environment in which the cells are treated. Resistance was not stable in a population and seemed to sensitise some cells to certain antibiotics. Antibacterial peptides enhanced the bactericidal effectiveness of an antibacterial gauze when used in tandem with a wetting agent and lysozyme. Results from this study suggest antibacterial peptides may have clinical applications as topical therapeutics.
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