Investigations into the therapeutic potential of antimicrobial peptides: applications for treating topical Staphylococcus aureus infections
|dc.contributor.author||Ravensdale, Joshua Thomas|
|dc.contributor.supervisor||Dr Frances O’Brien|
|dc.contributor.supervisor||Prof. Elizabeth Watkin|
|dc.contributor.supervisor||Dr Keith Gregg|
In this study, resistance towards antimicrobial peptides developed rapidly in MRSA, but resistance was mitigated by controlling the environment in which the cells are treated. Resistance was not stable in a population and seemed to sensitise some cells to certain antibiotics. Antibacterial peptides enhanced the bactericidal effectiveness of an antibacterial gauze when used in tandem with a wetting agent and lysozyme. Results from this study suggest antibacterial peptides may have clinical applications as topical therapeutics.
|dc.title||Investigations into the therapeutic potential of antimicrobial peptides: applications for treating topical Staphylococcus aureus infections|
|curtin.department||School of Biomedical Sciences|