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    Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort

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    Authors
    Robinson, C.
    Alfonso, Helman
    Woo, S.
    Olsen, N.
    Musk, A.
    Robinson, B.
    Nowak, A.
    Lake, R.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Robinson, C. and Alfonso, H. and Woo, S. and Olsen, N. and Musk, A. and Robinson, B. and Nowak, A. et al. 2014. Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort. Lung Cancer. 86 (1): pp. 29-34.
    Source Title
    Lung Cancer
    DOI
    10.1016/j.lungcan.2014.08.005
    ISSN
    0169-5002
    School
    Epidemiology and Biostatistics
    URI
    http://hdl.handle.net/20.500.11937/8706
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors have been associated with lower incidence rates of some cancers. Because asbestos can cause chronic inflammation at the pleural and peritoneal surfaces we hypothesised that NSAID and COX-2 inhibitors would inhibit the development of asbestos-induced mesothelioma. Materials and methods: A murine model of asbestos-induced mesothelioma was used to test this hypothesis by providing the NSAID, aspirin, daily in the feed at 50. mg/kg or 250. mg/kg. In a parallel study, the relationship between the use of NSAID and COX-2 inhibitors and mesothelioma was investigated in a human cohort of 1738 asbestos exposed people living or working in Wittenoom, Western Australia (a crocidolite mine site). Results: Aspirin did not alter the rate of disease development or increase the length of time that mice survived. Aspirin had a small but significant effect on disease latency (the time between asbestos exposure and first evidence of disease; p < 0.05) but disease progression was not affected by the continued presence of the drug. In the Wittenoom cohort, individuals who reported use of NSAIDs, COX-2 inhibitors or both did not have a lower incidence of mesothelioma (HR = 0.85; 95% CI = 0.53-1.37, p= 0.50), (HR = 0.69; 95% CI = 0.21-2.30, p= 0.55) and (HR = 0.43; 95% CI = 0.16-1.13, p= 0.087) respectively. Conclusion: We conclude that NSAIDs and COX-2 inhibitors do not moderate mesothelioma development or progression in a human cohort exposed to asbestos and this result is confirmed in an autochthonous mouse model.

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    • Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort
      Robinson, C.; Alfonso, Helman; Woo, S.; Olsen, N.; Bill Musk, A.; Robinson, B.; Nowak, A.; Lake, R. (2014)
      Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors have been associated with lower incidence rates of some cancers. Because asbestos can cause chronic inflammation at the pleural and peritoneal ...
    • Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans
      Robinson, C.; Alfonso, Helman; Woo, S.; Walsh, A.; Olsen, N.; Musk, A.; Robinson, B.; Nowak, A.; Lake, R. (2014)
      Mesothelioma is principally caused by asbestos and may be preventable because there is a long latent period between exposure and disease development. The most at-risk are a relatively well-defined population who were ...
    • The Wittenoom Legacy
      Musk, A.; Reid, A.; Olsen, N.; Hobbs, M.; Armstrong, B.; Franklin, P.; Hui, J.; Layman, L.; Brims, Fraser; Alfonso, H.; Shilkin, K.; Sodhi-Berry, N.; De Klerk, N. (2018)
      Introduction/Aim: In the fifty years since the Wittenoom crocidolite (blue asbestos) industry ceased operating, the epidemic of asbestos‐related diseases in Australia has intensified. Use of the employment records of the ...
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