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dc.contributor.authorWu, P.
dc.contributor.authorTsay, P.K.
dc.contributor.authorSun, Zhonghua
dc.contributor.authorPeng, S.J.
dc.contributor.authorLee, C.Y.
dc.contributor.authorHsu, M.Y.
dc.contributor.authorKo, Y.S.
dc.contributor.authorHsieh, I.C.
dc.contributor.authorWen, M.S.
dc.contributor.authorWan, Y.L.
dc.identifier.citationWu, P. and Tsay, P.K. and Sun, Z. and Peng, S.J. and Lee, C.Y. and Hsu, M.Y. and Ko, Y.S. et al. 2022. Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques. Diagnostics. 12 (390): Article No. 390.

Coronary computed tomography angiography (CCTA) is a widely used imaging modality for diagnosing coronary artery disease (CAD) but is limited by a high false positive rate when evaluating coronary arteries with stents and heavy calcifications. Virtual intravascular endoscopy (VIE) images generated from CCTA can be used to qualitatively assess the vascular lumen and might be helpful for overcoming this challenge. In this study, one hundred subjects with coronary stents underwent both CCTA and invasive coronary angiography (ICA). A total of 902 vessel segments were analyzed using CCTA and VIE. The vessel segments were first analyzed on CCTA alone. Then, using VIE, the segments were classified qualitatively as either negative or positive for in-stent restenosis (ISR) or CAD. These results were compared, using ICA as the reference, to determine the added diagnostic value of VIE. Of the 902 analyzed vessel segments, CCTA/VIE had sensitivity, specificity, accuracy, positive predictive value, and negative predictive value (shown in %) of 93.9/90.2, 96.2/98.2, 96.0/97.7, 70.0/83.1, and 99.4/99.0, respectively, in diagnosing ISR or CAD, with significantly improved specificity (p = 0.025), accuracy (p = 0.046), and positive predictive value (p = 0.047). VIE can be a helpful addition to CCTA when evaluating coronary arteries

dc.publisherMDPI AG
dc.subject3201 - Cardiovascular medicine and haematology
dc.titleAdded Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques
dc.typeJournal Article
curtin.departmentCurtin Medical School
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidSun, Zhonghua [0000-0002-7538-4761]
curtin.contributor.researcheridSun, Zhonghua [B-3125-2010]
curtin.contributor.scopusauthoridSun, Zhonghua [12544503300]

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