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    Protocol for transcranial direct current stimulation for obsessive-compulsive disorder

    87973.pdf (643.8Kb)
    Access Status
    Open access
    Authors
    Green, Peta
    Loftus, Andrea
    Anderson, Rebecca
    Date
    2020
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Green, P.E. and Loftus, A. and Anderson, R.A. 2020. Protocol for transcranial direct current stimulation for obsessive-compulsive disorder. Brain Sciences. 10 (12): Article No. 1008.
    Source Title
    Brain Sciences
    DOI
    10.3390/brainsci10121008
    ISSN
    2076-3425
    Faculty
    Faculty of Health Sciences
    School
    Curtin School of Population Health
    URI
    http://hdl.handle.net/20.500.11937/88171
    Collection
    • Curtin Research Publications
    Abstract

    Obsessive-compulsive disorder (OCD) is a debilitating disorder with an approximate lifetime prevalence of 1–3%. Despite advances in leading treatment modalities, including pharmacotherapy and psychotherapy, some cases remain treatment resistant. Non-invasive brain stimulation has been explored in this treatment-resistant population with some promising findings; however, a lack of methodological rigor has reduced the quality of the findings. The current paper presents the protocol for conducting research into the efficacy of transcranial direct current stimulation (tDCS) in the treatment of OCD. A double-blind randomised controlled trial (RCT) will be conducted involving active tDCS vs. sham tDCS on 40 general OCD patients. The intervention consists of 2 mA anodal stimulation over the pre-supplementary motor area (pre-SMA) with the cathode positioned over the orbitofrontal cortex (OFC). Participants will receive 10 sessions of 20 min of either sham-or active-tDCS over 4 weeks. Outcomes will be categorical and dimensional measures of OCD, as well as related secondary clinical measures (depression, anxiety, quality of life), and neurocognitive functions (inhibitory control, cognitive flexibility).

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