Towards the Development of an Integrative, Evidence-based Suite of Indicators for the Prediction of Outcome Following Mild Traumatic Brain Injury

Abstract

This thesis focuses on identifying factors that could be used to predict recovery following concussion. The first study is a pilot assessment of blood-based biomarkers, neuropsychological tests and MRI outcomes, followed by a protocol paper for a large scale clinical study designed to identify predictive indicators. The thesis features three journal publications, one of which is a seminal review article on a novel neuroimaging analysis technique called Quantitative Susceptibility Mapping.