Ageing and Mesothelioma Drive Lipid Accumulation and Dysfunction in Dendritic Cells and Macrophages
Access Status
Open access
Date
2022Supervisor
Delia Nelson
Connie Jackaman
Cyril Mamotte
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
The goal of this research was to examine the combined effect of ageing and mesothelioma (an untreatable and aggressive cancer) on key innate immune cells, namely macrophages and dendritic cells. Functional and metabolic changes to macrophages and dendritic cells in young and elderly hosts with or without mesothelioma were examined. The data show that mesothelioma compromised immune function, this was worsened by ageing.
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