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    Compatibility of pentoxifylline and parenteral medications

    Access Status
    Fulltext not available
    Authors
    Campbell, A.L.
    Petrovski, M.
    Senarathna, S.G.
    Mukadam, N.
    Strunk, T.
    Batty, Kevin
    Date
    2020
    Type
    Journal Article
    
    Metadata
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    Citation
    Campbell, A.L. and Petrovski, M. and Senarathna, S.G. and Mukadam, N. and Strunk, T. and Batty, K.T. 2020. Compatibility of pentoxifylline and parenteral medications. Archives of Disease in Childhood. 105 (4): pp. 395-397.
    Source Title
    Archives of Disease in Childhood
    DOI
    10.1136/archdischild-2019-317912
    ISSN
    0003-9888
    Faculty
    Faculty of Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/88946
    Collection
    • Curtin Research Publications
    Abstract

    Objective: To investigate the physical and chemical compatibility of pentoxifylline (PTX) with a range of parenteral medications used in neonatal intensive care.

    Design: PTX and drug solutions were combined in glass vials, inspected for physical incompatibility and evaluated on the basis of PTX concentrations for chemical compatibility.

    Results: No precipitation, colour change or turbidity was observed in any of the test mixtures. The PTX concentration was approximately 5.5% lower when combined with undiluted calcium gluconate injection (100 mg/mL). The PTX concentration ratios for all other combinations, including diluted calcium gluconate injection (50 mg/mL), were in the range of 99.5%-102%.

    Conclusion: In simulated Y-site conditions, PTX was found to be compatible with 15 parenteral medications and six total parenteral nutrition solutions. Based on PTX concentration tests, it would be prudent to avoid mixing PTX with undiluted calcium gluconate injection.

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