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    1H NMR-based metabonomic analysis of serum and urine in a nonhuman primate model of diabetic nephropathy

    Access Status
    Fulltext not available
    Authors
    Liu, J.
    Wang, D.
    Chen, Younan
    Sun, H.
    He, S.
    Wang, C.
    Yang, G.
    Shi, M.
    Zhang, J.
    Ren, Y.
    Wang, L.
    Lu, Y.
    Cheng, J.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Liu, J. and Wang, D. and Chen, Y. and Sun, H. and He, S. and Wang, C. and Yang, G. et al. 2013. 1H NMR-based metabonomic analysis of serum and urine in a nonhuman primate model of diabetic nephropathy. Molecular BioSystems. 9 (11): pp. 2645-2652.
    Source Title
    Molecular BioSystems
    DOI
    10.1039/c3mb70212j
    ISSN
    1742-206X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/8916
    Collection
    • Curtin Research Publications
    Abstract

    Diabetic nephropathy (DN) is a serious metabolic disease, and comprehensive understanding of its complex mechanism will help in preventing the onset and progression of DN. To reveal the systemic metabolic changes associated with renal injury, we performed 1H NMR-based metabonomic and multivariate analyses to analyze serum and urine obtained from a nonhuman primate model of DN. Our results indicated that DN monkeys exhibited a distinct metabolic profile, including higher levels of VLDL/LDL, lipids, unsaturated lipids, uric acid, allantoin, fumarate and hippurate, as well as lower levels of HDL, alanine, glutamate, pyruvate, formate, tyrosine, histidine and NAD+. The disturbed metabolic pathways were further identified, including NAD + metabolism, purine metabolism, oxidative stress, lipid metabolism, and renal tubular reabsorption. This study highlights that NMR-based metabonomics provides insight into the underlying pathways in the pathogenesis and progression of DN at the metabolic level.

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