Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid
Access Status
Open access
Authors
Kaliszczak, M.
Durand, P.
Wenger, E.
Dossot, M.
Jones, Franca
Arrigan, Damien
Herzog, G.
Date
2022Type
Journal Article
Metadata
Show full item recordCitation
Kaliszczak, M. and Durand, P. and Wenger, E. and Dossot, M. and Jones, F. and Arrigan, D.W.M. and Herzog, G. 2022. Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid. CrystEngComm. 24 (1): pp. 48-51.
Source Title
CrystEngComm
Faculty
Faculty of Science and Engineering
School
School of Molecular and Life Sciences (MLS)
Collection
Abstract
Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development.