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    Survival from uveal melanoma in Western Australia 1981–2005

    228482_228482a.pdf (873.0Kb)
    Access Status
    Open access
    Authors
    Chew, A.
    Spilsbury, Katrina
    Isaacs, T.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Chew, A. and Spilsbury, K. and Isaacs, T. 2015. Survival from uveal melanoma in Western Australia 1981–2005. Clinical and Experimental Ophthalmology. 43 (5): pp. 422-428.
    Source Title
    Clinical and Experimental Ophthalmology
    DOI
    10.1111/ceo.12490
    ISSN
    1442-6404
    School
    Centre for Population Health Research
    Remarks

    This is the peer reviewed version of the following article: Chew, A. and Spilsbury, K. and Isaacs, T. 2015. Survival from uveal melanoma in Western Australia 1981–2005. Clinical and Experimental Ophthalmology. 43 (5): pp. 422-428, which has been published in final form at http://doi.org/10.1111/ceo.12490. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms

    URI
    http://hdl.handle.net/20.500.11937/8985
    Collection
    • Curtin Research Publications
    Abstract

    Background: The survival rates for patients diagnosed with uveal melanoma in Australia are unknown. Few long-term studies of uveal melanoma are available, and it is unclear whether their results are applicable to the Australian population. Design: Retrospective population-based study. Participants: Patients diagnosed with uveal melanoma between 1981 and 2005 in Western Australia. Methods: Three hundred eight cases were included. Relative survival and Cox regression were performed. Variables tested for their predictive ability included patient age and sex, tumour-specific variables, and treatment modality. Main Outcome Measures: All-cause survival rates and relative survival rates of patients with diagnosed uveal melanoma. Results: Relative survival rates for the entire cohort were 88.2%, 81.4% and 71.4% at 3, 5 and 10 years, respectively. Predictors of worse survival included mixed-cell tumour morphology (hazard ratio [HR] = 2.1; P-value = 0.002), tumour location at the ciliary body (HR = 1.7; P-value = 0.029) and tumour apical height more than 5 mm (HR 1.9, P-value = 0.026). Of all patients who underwent enucleation, those diagnosed in 1998–2005 died twice as fast (HR = 2.3; P-value = 0.004). In the 17 patients with metastasis, the median survival time from date of diagnosis of metastasis was 3.1 months. Conclusions: These survival estimates are comparable to those reported for the USA, and more optimistic than those reported for most European-based studies. Tumour apical height, tumour site, tumour morphology and having an enucleation in certain calendar periods of diagnosis were independent predictors of survival. Survival prognosis for patients with diagnosed metastatic uveal melanoma is very poor.

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