Show simple item record

dc.contributor.authorSimpson-Yap, S.
dc.contributor.authorOddy, W.H.
dc.contributor.authorTaylor, B.
dc.contributor.authorLucas, R.M.
dc.contributor.authorBlack, Lucinda
dc.contributor.authorPonsonby, A.L.
dc.contributor.authorBlizzard, L.
dc.contributor.authorvan der Mei, I.
dc.contributor.authorDear, K.
dc.contributor.authorDwyer, T.
dc.contributor.authorBroadley, S.
dc.contributor.authorKilpatrick, T.
dc.contributor.authorWilliams, D.
dc.contributor.authorLechner-Scott, J.
dc.contributor.authorShaw, C.
dc.contributor.authorChapman, C.
dc.contributor.authorCoulthard, A.
dc.contributor.authorPender, M.P.
dc.contributor.authorValery, P.
dc.date.accessioned2023-01-16T06:05:53Z
dc.date.available2023-01-16T06:05:53Z
dc.date.issued2021
dc.identifier.citationSimpson-Yap, S. and Oddy, W.H. and Taylor, B. and Lucas, R.M. and Black, L.J. and Ponsonby, A.L. and Blizzard, L. et al. 2021. High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis. Multiple Sclerosis Journal. 27 (7): pp. 1112-1124.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/90048
dc.identifier.doi10.1177/1352458520943087
dc.description.abstract

Background: Dietary patterns and their association with subsequent clinical course have not been well studied in early multiple sclerosis (MS). Objectives: To describe dietary patterns in people in 5 years following first clinical demyelination and assess associations with MS conversion and relapse. Methods: This study included baseline food frequency questionnaire dietary intake (entry to the Ausimmune Study) and 5-year follow-up; iterated principal factor analysis was applied. MS conversion and relapse risks were assessed by Cox proportional hazards models, adjusted for age, sex, study site, education, body mass index (BMI), smoking and omega-3 supplement use. Results: In cases with a first clinical diagnosis of central nervous system (CNS) demyelination, we identified three major dietary patterns, ‘Prudent’, ‘High-Vegetable’ and ‘Mixed’, explaining 43%, 37% and 24% of diet variance in dietary intake, respectively. Fruits, vegetables, fish, wholegrains and nuts loaded highly on the Prudent pattern, starchy vegetables and legumes on the High-Vegetable pattern, and meats and alcohol on the Mixed pattern. Diet factor scores were not associated with MS conversion risk. Those with baseline Prudent scores above the median had significantly lower relapse risk (adjusted hazard ratio = 0.54, 95% confidence interval (CI) 0.37, 0.81) with some evidence of a plateau effect. Conclusion: Prudent diet factor score above the median was prospectively associated with lower relapse risk in the 5 years following the first clinical demyelinating event.

dc.languageEnglish
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.sponsoredbyhttp://purl.org/au-research/grants/nhmrc/316901
dc.relation.sponsoredbyhttp://purl.org/au-research/grants/nhmrc/224215
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectClinical Neurology
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.subjectDietary patterns
dc.subjectmultiple sclerosis
dc.subjectfactor analysis
dc.subjectMS conversion
dc.subjectrelapse
dc.subjectSUN EXPOSURE
dc.subjectRISK
dc.subjectPEOPLE
dc.subjectMULTICENTER
dc.subjectDIAGNOSIS
dc.subjectPATTERNS
dc.subjectCANCER
dc.subjectLIFE
dc.subjectFAT
dc.titleHigh Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis
dc.typeJournal Article
dcterms.source.volume27
dcterms.source.number7
dcterms.source.startPage1112
dcterms.source.endPage1124
dcterms.source.issn1352-4585
dcterms.source.titleMultiple Sclerosis Journal
dc.date.updated2023-01-16T06:05:52Z
curtin.note

This is an accepted manuscript of an article published by Sage in Multiple Sclerosis Journal on July 23, 2020 available online at https://doi.org/10.1177/1352458520943087

Simpson-Yap S, Oddy WH, Taylor B, et al. High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis. Multiple Sclerosis Journal. 2021;27(7):1112-1124. Copyright © 2020 The Authors. DOI: 10.1177/1352458520943087

curtin.departmentCurtin School of Population Health
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidBlack, Lucinda [0000-0003-4727-4773]
curtin.contributor.researcheridBlack, Lucinda [C-1930-2015]
curtin.identifier.article-numberARTN 1352458520943087
dcterms.source.eissn1477-0970
curtin.contributor.scopusauthoridBlack, Lucinda [23501520000]


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record