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dc.contributor.authorZhang, Guicheng
dc.contributor.authorHayden, C.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorHolt, P.
dc.contributor.authorLe Souëf, P.
dc.date.accessioned2017-01-30T11:10:36Z
dc.date.available2017-01-30T11:10:36Z
dc.date.created2016-01-18T20:00:38Z
dc.date.issued2011
dc.identifier.citationZhang, G. and Hayden, C. and Goldblatt, J. and Holt, P. and Le Souëf, P. 2011. Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes. ISRN Allergy. 2011: Article ID 405813.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/9119
dc.identifier.doi10.5402/2011/405813
dc.description.abstract

The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-?) on allergic phenotypes after adjusting for the correlations with Th2 cytokines. After adjusting for Th2 cytokines, IL-10 and IFN-? were protective against atopy. Adjusted levels of IL-10 and IFN-? stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P = 0.002), IL-13 (P = 0.012), IL-9 (P = 0.016), and IL-4 (P = 0.043), and for IFN-? adjusting for IL-5 (P = 0.005), IL-13 (P = 0.005), and IL-9 (P = 0.037). IL-10 and IFN-? levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern. The adjusted levels of IL-10 and IFN-? stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-? stimulated with SEB. Levels of Th2 cytokines distort the associations of IL-10 and IFN-? with allergic phenotypes. Removing the covariance with Th2 cytokines, both IL-10 and IFN-? were protective against atopy.

dc.titleTh2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
dc.typeJournal Article
dcterms.source.volume2011
dcterms.source.issn2090-5521
dcterms.source.titleISRN Allergy
curtin.note

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/3.0/

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access


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