Localization of a major susceptibility locus influencing preterm birth
MetadataShow full item record
Preterm birth (PTB) is a complex trait, but little is known regarding its major genetic determinants. The objective of this study is to localize genes that influence susceptibility to PTB in Mexican Americans (MAs), a minority population in the USA, using predominantly microfilmed birth certificate-based data obtained from the San Antonio Family Birth Weight Study. Only 1302 singleton births from 288 families with information on PTB and significant covariates were considered for genetic analysis. PTB is defined as a childbirth that occurs at <37 completed weeks of gestation, and the prevalence of PTB in this sample was 6.4%. An ∼10 cM genetic map was used to conduct a genome-wide linkage analysis using the program SOLAR. The heritability of PTB was high (h2 ± SE: 0.75 ± 0.20) and significant (P = 4.5 × 10−5), after adjusting for the significant effects of birthweight and birth order. We found significant evidence for linkage of PTB (LOD = 3.6; nominal P = 2.3 × 10−5; empirical P = 1.0 × 10−5) on chromosome 18q between markers D18S1364 and D18S541. Several other chromosomal regions (2q, 9p, 16q and 20q) were also potentially linked with PTB. A strong positional candidate gene in the 18q linked region is SERPINB2 or PAI-2, a member of the plasminogen activator system that is associated with various reproductive processes. In conclusion, to our knowledge, perhaps for the first time in MAs or US populations, we have localized a major susceptibility locus for PTB on chromosome 18q21.33-q23.
Showing items related by title, author, creator and subject.
The relationship of maternal micronutrient intakes of Vitamin B12, vitamin B6, folate and calcium on intrauterine growth retardation and birth weight : a prospective cohort study of urban South Indian pregnant womenDwarkanath, Pratibha (2011)The period of intrauterine growth and development is one of the most vulnerable periods in the human life cycle. The weight of the infant at birth is a powerful predictor of infant growth and survival, and is ...
Home or hospital? Midwife or physician? Preferences for maternity care provider and place of birth among Western Australian studentsStoll, K.; Hauck, Yvonne; Hall, W. (2015)© 2015. Background: Australian caesarean birth rates have exceeded 30% in most states and are approaching 45%, on average, in private hospitals. Australian midwifery practice occurs almost exclusively in hospitals; less ...
Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: Systematic review and meta-analysisMalacova, Eva; Regan, Annette; Nassar, N.; Raynes-Greenow, C.; Leonard, H.; Srinivasjois, R.; Shand, A.; Lavin, T.; Pereira, Gavin (2018)© 2018 Wolters Kluwer Health, Inc. All rights reserved. The leading cause of infant morbidity and mortality are stillbirth, preterm birth (PTB), and small for gestational age (SGA), which can occur as a result of fetal ...