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    Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination

    92577.pdf (269.9Kb)
    Access Status
    Open access
    Authors
    Daly, Alison
    Martin, Christopher
    Sherriff, Jill
    Mori, T.A.
    Pereira, Gavin
    Lucas, R.M.
    Ponsonby, A.L.
    Taylor, B.
    van der Mei, I.
    Black, Lucinda
    Ausimmune Investigator Group
    Date
    2021
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Daly, A. and Martin, C. and Sherriff, J. and Mori, T.A. and Pereira, G. and Lucas, R.M. and Ponsonby, A.L. et al. 2021. Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination. Multiple Sclerosis and Related Disorders. 55: ARTN 103210.
    Source Title
    Multiple Sclerosis and Related Disorders
    DOI
    10.1016/j.msard.2021.103210
    ISSN
    2211-0348
    Faculty
    Faculty of Health Sciences
    School
    Curtin School of Population Health
    Office of the Pro Vice Chancellor Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/92742
    Collection
    • Curtin Research Publications
    Abstract

    Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median (112 days), based on ATE, mean=5.30, 95% CI 5.08, 5.53; above median, mean=5.90, 95% CI 5.51, 6.30). Fish oil supplement use increased in a similar manner (at or below median (112 days), based on ATE, proportion=0.12, 95% CI 0.06, 0.18; above the median, proportion=0.21, 95% CI 0.14, 0.28). Our results suggest a behaviour change post FCD with increased use of fish oil supplements.

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