Show simple item record

dc.contributor.authorHo, Chau Le Bao
dc.contributor.authorReid, Christopher
dc.date.accessioned2023-08-31T03:28:26Z
dc.date.available2023-08-31T03:28:26Z
dc.date.issued2022
dc.identifier.citationBao Ho, C.L. and Reid, C.M. 2022. Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease. Exploration of Medicine. 3 (5): pp. 461-467.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/93104
dc.identifier.doi10.37349/emed.2022.00107
dc.description.abstract

Current evidence on benefits of night-time blood pressure (BP) lowering drug treatment on cardiovascular disease (CVD) prevention attributable to the Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy (MAPEC) trial and Bedtime hypertension treatment improves cardiovascular risk reduction (Hygia) trials has raised concern on their validity and methodology. In this commentary, the authors have updated the progress of the ongoing trials that were planned to examine the effect of night-time BP lowering drug treatment on CVD prevention. As compared to MAPEC and Hygia trials, three pragmatic trials the Blood Pressure Medication Timing (BPMedtime) trial (US), the Treatment In Morning versus Evening (TIME) trial (UK), Bedmed and Bedmed-frail (Canada) were planned without ambulatory BP monitoring. The BPMedtime trial was stopped after the pilot phase due to underestimated sample size and insufficient funds. TIME trial (UK) had a similar issue when changing the sample size from 10,269 to more than 20,000 participants. The TIME trial was completed and the initial results showing that protection against heart attack, stroke and vascular death is not affected by whether antihypertensive medications are taken in the morning or evening. The full study of the TIME trial is published in December 2022. Bedmed and Bedmed-frail trials are ongoing and will be completed in 2023. Time of taking BP lowering drug should be determined by patients at their convenience to improve the adherence. There was no difference in adverse effects of taking BP lowering drugs at night or morning. Evidence on the effect of night-time treatment on CVD events is inconsistent. The results from ongoing trials in Canada will contribute evidence to the use of BP lowering drug treatment for the prevention of CVD.

dc.relation.sponsoredbyhttp://purl.org/au-research/grants/nhmrc/1111170
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleUpdate on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease
dc.typeJournal Article
dcterms.source.volume3
dcterms.source.number5
dcterms.source.startPage461
dcterms.source.endPage467
dcterms.source.titleExploration of Medicine
dc.date.updated2023-08-31T03:28:26Z
curtin.departmentCurtin School of Population Health
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidReid, Christopher [0000-0001-9173-3944]
curtin.contributor.orcidHo, Chau Le Bao [0000-0001-7454-6995]
dcterms.source.eissn2692-3106
curtin.repositoryagreementV3


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/