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dc.contributor.authorPapa, Veronica
dc.contributor.authorGalassi, Francesco Maria
dc.contributor.authorVarotto, Elena
dc.contributor.authorGori, Andrea
dc.contributor.authorVaccarezza, Mauro
dc.date.accessioned2023-10-31T09:33:34Z
dc.date.available2023-10-31T09:33:34Z
dc.date.issued2023
dc.identifier.citationPapa, V. and Galassi, F.M. and Varotto, E. and Gori, A. and Vaccarezza, M. 2023. The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review. Pathogens and Immunity. 8 (1): pp. 93-116.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/93648
dc.identifier.doi10.20411/pai.v8i1.597
dc.description.abstract

Tuberculosis (TB) is an ancient chronic infectious disease that remains a global health concern. In human remains, the most common and characteristic clinical signs are the skeletal modifications involving the spine, such as in Pott’s disease. Diagnosing TB in ancient human remains is challenging. Therefore, in this systematic review, the authors investigated the studies assessing molecular diagnosis of Pott’s disease in ancient human remains with the intention to survey the literature, map the evidence, and identify gaps and future perspectives on TB in paleopathology. Our systematic review offers a full contextualization of the history of Pott’s disease in ancient times. Our search strategy was performed between August 2022 and March 2023. The authors initially identified 340 records, and 74 studies were finally included and assessed for qualitative analysis. Due to non-specific clinical signs associated with TB, how best to diagnose tuberculosis in human remains still represents a central point. Nevertheless, ancient DNA (aDNA) analysis, lipid biomarkers, and spoligotyping might be extremely useful tools in the study of TB in human remains. Moreover, we propose the extraction and study of immune response genes involved in innate and adaptive immunity versus Mycobacterium spp. as an innovative and vastly overlooked approach in TB paleopathology. Complementary methodologies should be integrated to provide the best approach to the study of TB in human remains.

dc.languageEnglish
dc.publisherPathogens and Immunity Case Western Reserve University Division of Infectious Diseases 10900 Euclid Ave. Mailstop 4984 Cleveland, OH 44106
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTuberculosis
dc.subjectspondylodiscitis; ancient DNA; Mycobacterium Tuberculosis Complex (MTBC); human remains
dc.titleThe Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number1
dcterms.source.startPage93
dcterms.source.endPage116
dcterms.source.issn2469-2964
dcterms.source.titlePathogens and Immunity
dcterms.source.placeUS
dc.date.updated2023-10-31T09:33:34Z
curtin.departmentCurtin Medical School
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]
curtin.repositoryagreementV3


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