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    An Absolutely Conserved Motif of the Essential Translocon Subunit, Sss1, Dictates Protein Function and Stability with Implications for Personalised Medicine

    Witham CM 2023 Public.pdf (5.514Mb)
    Access Status
    Open access
    Authors
    Witham, Christopher Michael
    Date
    2023
    Supervisor
    Carl Mousley
    Rob Steuart
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/93962
    Collection
    • Curtin Theses
    Abstract

    ER channels and components in translocation are frequently described with roles in disease progression. We have characterised a highly conserved region of the essential translocon subunit, Sss1, which encodes the proteins degron and contributes to regulating translocon dynamics. This work has utilised these findings to design a yeast-based system to identify novel regulators of translocon dynamics, assess the impact translocon dynamics has in disease and may have future applications as part of drug discovery.

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