An Absolutely Conserved Motif of the Essential Translocon Subunit, Sss1, Dictates Protein Function and Stability with Implications for Personalised Medicine

Abstract

ER channels and components in translocation are frequently described with roles in disease progression. We have characterised a highly conserved region of the essential translocon subunit, Sss1, which encodes the proteins degron and contributes to regulating translocon dynamics. This work has utilised these findings to design a yeast-based system to identify novel regulators of translocon dynamics, assess the impact translocon dynamics has in disease and may have future applications as part of drug discovery.