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    Genetic association of preeclampsia to the inflammatory response gene SEPS1

    Access Status
    Fulltext not available
    Authors
    Moses, Eric
    Johnson, M.
    Tømmerdal, L.
    Forsmo, S.
    Curran, J.
    Abraham, L.
    Charlesworth, J.
    Brennecke, S.
    Blangero, J.
    Austgulen, R.
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Moses, E. and Johnson, M. and Tømmerdal, L. and Forsmo, S. and Curran, J. and Abraham, L. and Charlesworth, J. et al. 2008. Genetic association of preeclampsia to the inflammatory response gene SEPS1. American Journal of Obstetrics and Gynecology. 198 (3): pp. 336.e1-336.e5.
    Source Title
    American Journal of Obstetrics and Gynecology
    DOI
    10.1016/j.ajog.2007.09.024
    ISSN
    0002-9378
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/9411
    Collection
    • Curtin Research Publications
    Abstract

    Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by ?2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population. © 2008 Mosby, Inc. All rights reserved.

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