Genetic association of preeclampsia to the inflammatory response gene SEPS1

Moses, E. and Johnson, M. and Tømmerdal, L. and Forsmo, S. and Curran, J. and Abraham, L. and Charlesworth, J. et al. 2008. Genetic association of preeclampsia to the inflammatory response gene SEPS1. American Journal of Obstetrics and Gynecology. 198 (3): pp. 336.e1-336.e5.

Source Title

American Journal of Obstetrics and Gynecology

DOI

10.1016/j.ajog.2007.09.024

ISSN

0002-9378

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/9411

Collection

Curtin Research Publications

Abstract

Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by ?2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population. © 2008 Mosby, Inc. All rights reserved.