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    Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials

    Access Status
    Fulltext not available
    Authors
    Pathak, K.
    Soares, Mario
    Calton, Emily
    Zhao, Yun
    Hallett, Jonathan
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Pathak, K. and Soares, M. and Calton, E. and Zhao, Y. and Hallett, J. 2014. Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews. 15 (6): pp. 528-537.
    Source Title
    Obesity Reviews
    DOI
    10.1111/obr.12162
    ISSN
    1467-7881
    URI
    http://hdl.handle.net/20.500.11937/9440
    Collection
    • Curtin Research Publications
    Abstract

    Vitamin D is anticipated to have many extra-skeletal health benefits. We questioned whether supplementation with the vitamin influenced body weight and composition. A systematic review and meta-analysis was conducted on high-quality, randomized controlled trials (RCTs) that had supplemented vitamin D without imposing any caloric restriction. Eighteen trials reporting either body weight, body mass index (BMI), fat mass (FM), percentage fat mass (%FM) or lean body mass (LBM) met our criteria. Twelve studies provided the required data for the meta-analysis. Vitamin D supplementation did not influence the standardized mean difference (SMD) for body weight, FM, %FM or LBM. A small but non-significant decrease in BMI (SMD = -0.097, 95% confidence interval: [-0.210, 0.016], P = 0.092) was observed. Meta-regression confirmed that neither the absolute vitamin D status achieved nor its change from baseline influenced the SMD of any obesity measure. However, increasing age of the subjects predicted a shift in the SMD for FM towards the placebo treatment, whereas a greater percentage of women in these studies favoured a decrease in FM following vitamin D. Vitamin D supplementation did not decrease measures of adiposity in the absence of caloric restriction. A potential confounding by age and gender was encountered.

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