The Effect of Naturally Occurring Osmolytes and Organic Solvents on the Structure and Folding of Intrinsically Disordered Proteins

Abstract

The thesis looks into amylin, a type of protein linked to type-2 diabetes. Using computer simulations, the study examines the individual forms of amylin in both humans and rats. The research validates the methods and looks at how different chemicals HFIP, TMAO and urea affects amylin structure. The results provide a better understanding of amylin's basic form, how it changes in different conditions.