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dc.contributor.authorSpackman, Peter
dc.contributor.authorWalisinghe, A.J.
dc.contributor.authorAnderson, M.W.
dc.contributor.authorGale, Julian
dc.date.accessioned2024-04-09T07:05:04Z
dc.date.available2024-04-09T07:05:04Z
dc.date.issued2023
dc.identifier.citationSpackman, P.R. and Walisinghe, A.J. and Anderson, M.W. and Gale, J.D. 2023. CrystalClear: an open, modular protocol for predicting molecular crystal growth from solution. Chemical Science. 14 (26): pp. 7192-7207.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/94789
dc.identifier.doi10.1039/d2sc06761g
dc.description.abstract

We present a new protocol for the prediction of free energies that determine the growth of sites in molecular crystals for subsequent use in Monte Carlo simulations using tools such as CrystalGrower [Hill et al., Chemical Science, 2021, 12, 1126-1146]. Key features of the proposed approach are that it requires minimal input, namely the crystal structure and solvent only, and provides automated, rapid generation of the interaction energies. The constituent components of this protocol, namely interactions between molecules (growth units) in the crystal, solvation contributions and treatment of long-range interactions are described in detail. The power of this method is shown via prediction of crystal shapes for ibuprofen grown from ethanol, ethyl acetate, toluene and acetonitrile, adipic acid grown from water, and five polymorphs (ON, OP, Y, YT04 and R) of ROY (5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile), with promising results. The predicted energies may be used directly or subsequently refined against experimental data, facilitating insight into the interactions governing crystal growth, while also providing a prediction of the solubility of the material. The protocol has been implemented in standalone, open-source software made available alongside this publication.

dc.languageeng
dc.relation.sponsoredbyhttp://purl.org/au-research/grants/arc/FL180100087
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleCrystalClear: an open, modular protocol for predicting molecular crystal growth from solution
dc.typeJournal Article
dcterms.source.volume14
dcterms.source.number26
dcterms.source.startPage7192
dcterms.source.endPage7207
dcterms.source.issn2041-6520
dcterms.source.titleChemical Science
dc.date.updated2024-04-09T07:05:00Z
curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidSpackman, Peter [0000-0002-6532-8571]
curtin.contributor.orcidGale, Julian [0000-0001-9587-9457]
dcterms.source.eissn2041-6539
curtin.contributor.scopusauthoridSpackman, Peter [56658699700]
curtin.contributor.scopusauthoridGale, Julian [7101993408]
curtin.repositoryagreementV3


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