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dc.contributor.authorChoudhury, M.
dc.contributor.authorBrunton, Paul
dc.contributor.authorSchwass, D.
dc.contributor.authorPletzer, D.
dc.contributor.authorRatnayake, J.
dc.contributor.authorDias, G.
dc.contributor.authorTompkins, G.
dc.date.accessioned2024-04-23T02:20:55Z
dc.date.available2024-04-23T02:20:55Z
dc.date.issued2024
dc.identifier.citationChoudhury, M. and Brunton, P. and Schwass, D. and Pletzer, D. and Ratnayake, J. and Dias, G. and Tompkins, G. 2024. Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review. Systematic Reviews. 13 (1): pp. 39-.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/94901
dc.identifier.doi10.1186/s13643-023-02425-9
dc.description.abstract

Background: Oral mucositis remains a significant complication during cancer therapy with no effective treatment. Gold nanoparticles offer anti-inflammatory, antioxidant properties with low toxicity. This study systematically reviews the literature assessing gold nanoparticles in the management of oral mucositis in animal models. Methods: A literature search was undertaken using MEDLINE, Embase, PubMed, and Web of Science databases, using the format for Systematic Review Centre for Laboratory Animal Experimentation. Prior to the review, the protocol was registered in the systematic review register, PROSPERO (registration no. CRD42021272169). Outcome measures included ulceration, histopathological scores, inflammatory mediators, microbial growth, and pain. Study quality was analysed by SYRCLE risk-of-bias tool. Results: Only one study met the inclusion criteria, documenting reduction in ulceration, inflammatory, and oxidative biomarkers. Exposure to AuNPs prevented inflammatory response induced by 5-fluorouracil in oral mucosa of hamsters. However, a high risk of bias necessitates further research. Conclusion: This review identifies a potential therapeutic strategy for prevention and management of oral mucositis. It also provides future direction for gold nanoparticle research in oral mucositis; however, there is lack of sufficient evidence to derive any conclusion. Research with standardized parameters including nanoparticle size, capping agent, surface charge, and appropriate oral mucositis animal models will establish risk–benefit balance and margin of safety for therapeutic use of gold nanoparticles for oral mucositis.

dc.languageeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnimal model
dc.subjectGold nanoparticles
dc.subjectOral mucositis
dc.subjectSystematic review
dc.subjectAnimals
dc.subjectGold
dc.subjectNeoplasms
dc.subjectMetal Nanoparticles
dc.subjectStomatitis
dc.subjectMouth Mucosa
dc.subjectMouth Mucosa
dc.subjectAnimals
dc.subjectNeoplasms
dc.subjectStomatitis
dc.subjectGold
dc.subjectMetal Nanoparticles
dc.titleEffectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review
dc.typeJournal Article
dcterms.source.volume13
dcterms.source.number1
dcterms.source.startPage39
dcterms.source.issn2046-4053
dcterms.source.titleSystematic Reviews
dc.date.updated2024-04-23T02:20:51Z
curtin.departmentOffice of the Deputy Vice-Chancellor, Academic
curtin.accessStatusOpen access
curtin.facultyOffice of the Deputy Vice-Chancellor, Academic
curtin.contributor.orcidBrunton, Paul [0000-0001-9726-2987]
dcterms.source.eissn2046-4053
curtin.contributor.scopusauthoridBrunton, Paul [7003684965]
curtin.repositoryagreementV3


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