Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

    Access Status
    Fulltext not available
    Authors
    Macedo-Vinas, M.
    Conly, J.
    Francois, P.
    Aschbacher, R.
    Blanc, D.
    Coombs, Geoffrey
    Daikos, G.
    Dhawan, B.
    Empel, J.
    Etienne, J.
    Figueiredo, A.
    Golding, G.
    Han, L.
    Kim, H.
    Kock, R.
    Larsen, A.
    Layer, F.
    Lo, J.
    Maeda, T.
    Mulvey, M.
    Pantosti, A.
    Saga, T.
    Schrenzel, J.
    Simor, A.
    Skov, R.
    Van Rijen, M.
    Wang, H.
    Zakaria, Z.
    Harbarth, S.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Macedo-Vinas, M. and Conly, J. and Francois, P. and Aschbacher, R. and Blanc, D. and Coombs, G. and Daikos, G. et al. 2014. Antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey. Journal of Global Antimicrobial Resistance. 2: pp. 43-47.
    Source Title
    Journal of Global Antimicrobial Resistance
    DOI
    10.1016/j.jgar.2013.08.003
    ISSN
    2213-7165
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/9524
    Collection
    • Curtin Research Publications
    Abstract

    The antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) isolates reported from 17 countries in the Americas, Europe and, Australia-Asia were analysed. Among a total of 3236 non-duplicate isolates, the lowest susceptibility was observed to erythromycin in all regions. Susceptibility to ciprofloxacin showed large variation (25%, 75% and 84% in the Americas, Europe and Australia-Asia, respectively). Two vancomycin- intermediate PVL-positive MRSA isolates were reported, one from Hong Kong and the other from The Netherlands. Resistance to trimethoprim/sulfamethoxazole and linezolid was <1%. Among 1798 MRSA isolates from 13 countries that were tested for the requested 10 non-b-lactam antibiotics, 49.4% were multisusceptible. However, multiresistant isolates (resistant to at least three classes of non-b-lactam antibiotics) were reported from all regions. Sequence type 30 (ST30) was reported worldwide, whereas ST80 and ST93 were exclusive to Europe and Australia, respectively. USA300 and related clones (ST8) are progressively replacing the ST80 clone in several European countries. Eight major clusters were discriminated by multilocus variable-number tandem repeat assay (MLVA), showing a certain geographic specificity. PVL-positive MRSA isolates frequently remain multisusceptible to non-b-lactam agents, but multiresistance is already prevalent in all regions. Surveillance of MRSA susceptibility patterns should be monitored to provide clinicians with the most current information regarding changes in resistance patterns

    Related items

    Showing items related by title, author, creator and subject.

    • The Australian community methicillin resistant Staphylococcus aureus endemic : clonal spread or multiple evolutionary events
      Coombs, Geoffrey Wallace (2012)
      Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was first reported in remote indigenous communities living in the sparsely populated Kimberley region of Western Australia (WA). Between 1989 and ...
    • Australian Group on Antimicrobial Resistance Hospital-onset Staphylococcus aureus Surveillance Programme annual report, 2011
      Coombs, Geoffrey; Nimmo, G.; Pearson, J.; Collignon, P.; Bell, J.; McLaws, M.; Christiansen, K.; Turnidge, J. (2013)
      In 2011, the Australian Group on Antimicrobial Resistance (AGAR) conducted a period-prevalence survey of clinical Staphylococcus aureus isolated from hospital inpatients. Twenty-nine microbiology laboratories from all ...
    • Molecular characterization of Malaysian methicillin-resistant Staphylococcus aureus
      Lim, Tien Tze (2007)
      Seventy-four methicillin-resistant Staphylococcus aureus (MRSA) from two Malaysian hospitals were characterised by both phenotypic and genotypic techniques. These isolates were collected over an 18 year time period in the ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.