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    Dietary flavonoids and nitrate: effects on nitric oxide and vascular function

    Access Status
    Fulltext not available
    Authors
    Bondonno, C.
    Croft, K.
    Ward, Natalie
    Considine, M.
    Hodgson, J.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Bondonno, C. and Croft, K. and Ward, N. and Considine, M. and Hodgson, J. 2015. Dietary flavonoids and nitrate: effects on nitric oxide and vascular function. Nutrition Reviews. 73 (4): pp. 216-235.
    Source Title
    Nutrition reviews
    DOI
    10.1093/nutrit/nuu014
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/9540
    Collection
    • Curtin Research Publications
    Abstract

    Emerging evidence highlights dietary flavonoids and nitrate as candidates that may explain at least part of the cardioprotective effect of a fruit and vegetable diet. Nitric oxide plays a pivotal role in cardiovascular health. Components of a fruit and vegetable diet that are cardioprotective, in part through effects on nitric oxide status, could substantially reduce the cardiovascular risk profile of the general population with increased intake of such a diet. Epidemiological evidence suggests that dietary flavonoids and nitrate have a cardioprotective effect. Clinical trials with flavonoid- and nitrate-rich foods have shown benefits on measures of vascular health. While the molecular mechanisms by which flavonoids and nitrate are cardioprotective are not completely understood, recent evidence suggests both nonspecific and specific effects through nitric oxide pathways. This review presents an overview of nitric oxide and its key role in cardiovascular health and discusses the possible vascular benefits of flavonoids and nitrate, individually and in combination, through effects on nitric oxide status.

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