Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes
MetadataShow full item record
Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p ≤ uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key message: Chromosome 9p21 is not associated with preeclampsia.
Showing items related by title, author, creator and subject.
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsiaThomsen, L.; Mccarthy, N.; Melton, P.; Cadby, G.; Austgulen, R.; Nygård, O.; Johnson, M.; Brennecke, S.; Moses, Eric; Bjørge, L.; Iversen, A. (2016)Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing ...
Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13qFenstad, M.; Johnson, M.; Roten, L.; Aas, P.; Forsmo, S.; Klepper, K.; East, C.; Abraham, L.; Blangero, J.; Brennecke, S.; Austgulen, R.; Moses, Eric (2010)Background: Preeclampsia is a serious pregnancy complication, demonstrating a complex pattern of inheritance. The elucidation of genetic liability to preeclampsia remains a major challenge in obstetric medicine. We have ...
A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)Roten, L.; Fenstad, M.; Forsmo, S.; Johnson, M.; Moses, Eric; Austgulen, R.; Skorpen, F. (2011)The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and ...