Mechanisms of Cancer-Associated Thrombosis: Role of Cancer-Derived Exosomes
| dc.contributor.author | Abdol Razak, Norbaini Binti | |
| dc.contributor.supervisor | Pat Metharom | en_US |
| dc.contributor.supervisor | Giuseppe Verdile | en_US |
| dc.date.accessioned | 2024-09-25T07:22:15Z | |
| dc.date.available | 2024-09-25T07:22:15Z | |
| dc.date.issued | 2024 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/95952 | |
| dc.description.abstract |
This thesis investigated the effect of pancreatic cancer-derived exosomes on cells that are known to play roles in thrombosis. Together, the results demonstrate that PDEx have a range of effects on neutrophils, platelets and endothelial cells. Overall they can modulate the function of these cells to have procoagulant properties, suggesting that PDEx has a significant function in promoting thrombosis and can potentially be targeted for therapeutic intervention cancer-associated thrombosis. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Mechanisms of Cancer-Associated Thrombosis: Role of Cancer-Derived Exosomes | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | Curtin Medical School | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |
| curtin.contributor.orcid | Abdol Razak, Norbaini Binti [0000-0002-3133-9790] | en_US |