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    Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications

    Elaskalani O 2019.pdf (14.05Mb)
    Access Status
    Open access
    Authors
    Elaskalani, Omar
    Date
    2019
    Supervisor
    Pat Metharom
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/77186
    Collection
    • Curtin Theses
    Abstract

    Platelets are small anucleate blood cells that are central to primary haemostasis. However, platelets are also implicated in cancer pathogenesis. This thesis showed that cancer cells promote thrombosis by activating platelets, and in turn, platelets provide cancer cells with growth factors to render cancer more aggressive and chemoresistant. The thesis demonstrated a therapeutic benefit of combined antiplatelet, ticagrelor, and chemo drugs, on cancer treatment.

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      Elaskalani, Omar; Falasca, Marco; Moran, N.; Berndt, Michael; Metharom, Pat (2017)
      Platelets have been demonstrated to be vital in cancer epithelial-mesenchymal transition (EMT), an important step in metastasis. Markers of EMT are associated with chemotherapy resistance. However, the association between ...
    • The functional role of platelets in the regulation of angiogenesis
      Walsh, T.; Metharom, Pat; Berndt, Michael (2015)
      Functionally, platelets are primarily recognized as key regulators of thrombosis and hemostasis. Upon vessel injury, the typically quiescent platelet interacts with subendothelial matrix to regulate platelet adhesion, ...
    • Pancreatic cancer-induced neutrophil extracellular traps: A potential contributor to cancer-associated thrombosis
      Razak, N.; Elaskalani, O.; Metharom, Pat (2017)
      Pancreatic cancer (PaCa) is a highly metastatic cancer, and patients are at high risk of developing venous thromboembolism (VTE). Neutrophil extracellular traps (NETs) have been associated with cancer metastasis and ...
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