Bile acids for probucol formulations applications in drug induced ototoxicity

Abstract

Within this thesis, probucol’s otoprotective application is assessed in vitro on House Ear Institute-Organ of Corti 1 (HEI-OC1) using three different formulation methods; 1) spray dried, 2) chitosan films or 3) supramolecular aggregates. To improve pre-formulation stability and drug loading, probucol is tested in combination with unconjugated and conjugated bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, lithocholic acid).