Bile acids for probucol formulations applications in drug induced ototoxicity
Access Status
Open access
Date
2024Supervisor
Hani Al-Salami
Armin Mooranian
Daniel Brown
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
Curtin Medical School
Collection
Abstract
Within this thesis, probucol’s otoprotective application is assessed in vitro on House Ear Institute-Organ of Corti 1 (HEI-OC1) using three different formulation methods; 1) spray dried, 2) chitosan films or 3) supramolecular aggregates. To improve pre-formulation stability and drug loading, probucol is tested in combination with unconjugated and conjugated bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, lithocholic acid).
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