Bile acids for probucol formulations applications in drug induced ototoxicity
| dc.contributor.author | Ionescu, Corina Mihaela | |
| dc.contributor.supervisor | Hani Al-Salami | en_US |
| dc.contributor.supervisor | Armin Mooranian | en_US |
| dc.contributor.supervisor | Daniel Brown | en_US |
| dc.date.accessioned | 2024-10-07T02:36:05Z | |
| dc.date.available | 2024-10-07T02:36:05Z | |
| dc.date.issued | 2024 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/96021 | |
| dc.description.abstract |
Within this thesis, probucol’s otoprotective application is assessed in vitro on House Ear Institute-Organ of Corti 1 (HEI-OC1) using three different formulation methods; 1) spray dried, 2) chitosan films or 3) supramolecular aggregates. To improve pre-formulation stability and drug loading, probucol is tested in combination with unconjugated and conjugated bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, lithocholic acid). | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Bile acids for probucol formulations applications in drug induced ototoxicity | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | Curtin Medical School | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |
| curtin.contributor.orcid | Ionescu, Corina Mihaela [0000-0002-8966-0448] | en_US |